Key challenges in the outbound pharmaceutical cold chain
- Authors: Kosmas, Sarantis
- Date: 2016
- Subjects: Business logistics , Refrigerated transport , Drugs - Equipment and supply
- Language: English
- Type: Masters (Thesis)
- Identifier: http://hdl.handle.net/10210/237630 , uj:24349
- Description: M.Com. (Logistics Management) , Abstract: The South African pharmaceutical cold chain industry has a fundamental challenge in balancing the quality requirements, driven by the Medicines Control Council (MCC), within a constrained revenue model that caps the possible income from distribution activities through single exit pricing (SEP) regulations. This research seeks to understand the key challenges in the pharmaceutical cold chain industry. Through the use of a survey and cost analysis, both a qualitative and quantitative view of the research on the outbound distribution operations for fine distribution, distribution to pharmacies and hospitals, of cold chain pharmaceuticals were obtained. The research takes a structured approach to identifying relationships between various elements of the pharmaceutical cold chain, as well as ascertaining the key factors and risk ratings of these elements. This information was analysed to identify the key challenges in the pharmaceutical cold chain industry. Using the Lambert and Stock total cost model, a framework was developed to guide both the survey and cost analysis research. As both components were structured in this manner, these components could be cross-referenced for consistency. The findings of the research identified that there was a significant relationship between the outbound distribution and the quality elements of the supply chain. The most important key factors were determined to be transportation volume, product write-offs, cold room validation, duration of the cold chain packaging system, type of temperature monitoring equipment, and cold room and freezer storage. The key risks were identified as being in the transport, validation/qualification and cold chain packaging elements. The research concluded that quality elements related to the warehousing function are well controlled, while the highest risk is within the transportation element. The research successfully identified six key challenges all related to the transportation element of the pharmaceutical cold chain industry. These challenges related to cold chain packaging, temperature monitoring as well as validation/qualification of cold chain packaging systems.
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- Authors: Kosmas, Sarantis
- Date: 2016
- Subjects: Business logistics , Refrigerated transport , Drugs - Equipment and supply
- Language: English
- Type: Masters (Thesis)
- Identifier: http://hdl.handle.net/10210/237630 , uj:24349
- Description: M.Com. (Logistics Management) , Abstract: The South African pharmaceutical cold chain industry has a fundamental challenge in balancing the quality requirements, driven by the Medicines Control Council (MCC), within a constrained revenue model that caps the possible income from distribution activities through single exit pricing (SEP) regulations. This research seeks to understand the key challenges in the pharmaceutical cold chain industry. Through the use of a survey and cost analysis, both a qualitative and quantitative view of the research on the outbound distribution operations for fine distribution, distribution to pharmacies and hospitals, of cold chain pharmaceuticals were obtained. The research takes a structured approach to identifying relationships between various elements of the pharmaceutical cold chain, as well as ascertaining the key factors and risk ratings of these elements. This information was analysed to identify the key challenges in the pharmaceutical cold chain industry. Using the Lambert and Stock total cost model, a framework was developed to guide both the survey and cost analysis research. As both components were structured in this manner, these components could be cross-referenced for consistency. The findings of the research identified that there was a significant relationship between the outbound distribution and the quality elements of the supply chain. The most important key factors were determined to be transportation volume, product write-offs, cold room validation, duration of the cold chain packaging system, type of temperature monitoring equipment, and cold room and freezer storage. The key risks were identified as being in the transport, validation/qualification and cold chain packaging elements. The research concluded that quality elements related to the warehousing function are well controlled, while the highest risk is within the transportation element. The research successfully identified six key challenges all related to the transportation element of the pharmaceutical cold chain industry. These challenges related to cold chain packaging, temperature monitoring as well as validation/qualification of cold chain packaging systems.
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The interaction between supply chain management and manufacturing planning in an electronic defence systems company
- Authors: Mashinini, M.E.
- Date: 2012
- Subjects: Business logistics - Management
- Language: English
- Type: Masters (Thesis)
- Identifier: http://hdl.handle.net/10210/295127 , uj:32128
- Description: M.Com. (Business Management) , Abstract: Many manufacturing companies around the world, including South African companies, experience a shortfall in desired outcomes in relation to the potential supply chain management benefits that contribute to efficient manufacturing planning and improved delivery performance. These benefits can be translated into an improved balance sheet, income statement and cash flow. Most companies are aware of the view that supply chain excellence yields more economic benefits by directly linking the benefits of increased shareholder value, but lack the understanding of how to unleash the power of the integrated supply chain approach and systematic intervention. As stated by Slone, Dittmann, and Mentzer (2010:7), the supply chain controls up to 70% of the operating cost, including inventory management, and manages most of the physical assets of the business. However, little research currently exists in terms of directly linking the benefits of best fit between supply chain management and a manufacturing planning approach in an engineering-to-order manufacturing environment. This dissertation investigates the misalignment between supply chain management and manufacturing planning in an electronic defence company. This study addresses the possible shortfalls in the interaction between the supply chain management approach and the manufacturing planning approach at an electronic defence systems company and focuses on supply chain planning, manufacturing planning, the influence of design and development and the silo organizational structure. Relevant supply chain management interventions are investigated through a literature review, including the supply chain management approach, the value chain and manufacturing planning. The study was conducted in two ways: Firstly, the relevant literature was reviewed and, secondly, an empirical study was conducted at the research site by administering self-administered questionnaires to selected respondents and by collecting data from the enterprise resource planning (ERP) system to gain a rich understanding of the problem addressed by this research...
- Full Text:
- Authors: Mashinini, M.E.
- Date: 2012
- Subjects: Business logistics - Management
- Language: English
- Type: Masters (Thesis)
- Identifier: http://hdl.handle.net/10210/295127 , uj:32128
- Description: M.Com. (Business Management) , Abstract: Many manufacturing companies around the world, including South African companies, experience a shortfall in desired outcomes in relation to the potential supply chain management benefits that contribute to efficient manufacturing planning and improved delivery performance. These benefits can be translated into an improved balance sheet, income statement and cash flow. Most companies are aware of the view that supply chain excellence yields more economic benefits by directly linking the benefits of increased shareholder value, but lack the understanding of how to unleash the power of the integrated supply chain approach and systematic intervention. As stated by Slone, Dittmann, and Mentzer (2010:7), the supply chain controls up to 70% of the operating cost, including inventory management, and manages most of the physical assets of the business. However, little research currently exists in terms of directly linking the benefits of best fit between supply chain management and a manufacturing planning approach in an engineering-to-order manufacturing environment. This dissertation investigates the misalignment between supply chain management and manufacturing planning in an electronic defence company. This study addresses the possible shortfalls in the interaction between the supply chain management approach and the manufacturing planning approach at an electronic defence systems company and focuses on supply chain planning, manufacturing planning, the influence of design and development and the silo organizational structure. Relevant supply chain management interventions are investigated through a literature review, including the supply chain management approach, the value chain and manufacturing planning. The study was conducted in two ways: Firstly, the relevant literature was reviewed and, secondly, an empirical study was conducted at the research site by administering self-administered questionnaires to selected respondents and by collecting data from the enterprise resource planning (ERP) system to gain a rich understanding of the problem addressed by this research...
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