Hope and ways of coping after breast cancer
- Authors: Rubin, Hayley Harriet
- Date: 2008-11-12T08:47:53Z
- Subjects: Breast cancer , Breast cancer treatment , Adjustment (Psychology) , Hope
- Type: Thesis
- Identifier: uj:14665 , http://hdl.handle.net/10210/1638
- Description: M.A. , The aim of this study was to ascertain the coping methods of women in long term follow-up of breast cancer treatment. Furthermore, personality traits that deal with the spectrum of positive affectivity were introduced to determine whether these impact on women's appraisal of their situation and their subsequent choice of coping mechanism. Thus, a process approach to exploring coping strategies and a goal-attainment conceptualization of hope were used to determine whether hope is associated with coping appraisal in the long term follow-up of breast cancer treatment. Furthermore, high hope women were expected to use more problem focused coping methods and low hope women were expected to use more emotion focused coping skills. Women in cancer remission who attend yearly or six-monthly check-ups at the Johannesburg hospital were approached to complete the questionnaire and brief interview. Although the study did not confirm that low hope and high hope women use different kinds of coping strategies, the predicted relationship between hope and challenge appraisals was supported by significant correlations. However, it was found that hope may be analogous to positive affect, thus indicating the need for further validation of the Hope Scale. Finally, it was concluded that breast cancer need not be seen as a devitalising disease and that there are a variety of coping strategies which can be utilized to enhance patient's positive emotional state. The women in this study use the emotion focused coping skill of positive reappraisal which concentrates on the possibilities for mastery and growth that inhere in their long term follow-up treatment. Moreover, women are extremely positive and hopeful in their daily outlook and while this personality trait seems to suggest that denial is at play, it is more likely that women in long term remission have a strong belief in their own personal qualities and future. Women in this study choose to distance themselves from the implicit trauma of the threat of recurrence in favour of an active belief in their personal resilience to overcome any stressful event or outcome.
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Photobiomodulation of breast and cervical cancer stem cells using low-intensity laser irradiation
- Authors: Kiro, N. E. , Hamblin, M. R. , Abrahamse, H.
- Date: 2017
- Subjects: Stem cells , Cancer stem cells , Breast cancer
- Language: English
- Type: Article
- Identifier: http://hdl.handle.net/10210/249491 , uj:25964 , Citation: Kiro, N.E., Hamblin, M.R. & Abrahamse, H. 2017. Photobiomodulation of breast and cervical cancer stem cells using low-intensity laser irradiation. Tumor Biology, DOI:10.1177/1010428317706913
- Description: Abstract: Breast and cervical cancers are dangerous threats with regard to the health of women. The two malignancies have reached the highest record in terms of cancer-related deaths among women worldwide. Despite the use of novel strategies with the aim to treat and cure advanced stages of cancer, post-therapeutic relapse believed to be caused by cancer stem cells is one of the challenges encountered during tumor therapy. Therefore, further attention should be paid to cancer stem cells when developing novel anti-tumor therapeutic approaches. Low-intensity laser irradiation is a form of phototherapy making use of visible light in the wavelength range of 630–905 nm. Low-intensity laser irradiation has shown remarkable results in a wide range of medical applications due to its biphasic dose and wavelength effect at a cellular level. Overall, this article focuses on the cellular responses of healthy and cancer cells after treatment with lowintensity laser irradiation alone or in combination with a photosensitizer as photodynamic therapy and the influence that various wavelengths and fluencies could have on the therapeutic outcome. Attention will be paid to the biomodulative effect of low-intensity laser irradiation on cancer stem cells.
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Photodynamic therapy, a potential therapy for improve cancer management
- Authors: Abrahamse, Heidi , Mfouo Tynga, Ivan Sosthene
- Date: 2018
- Subjects: Cancer , Breast cancer , Current treatment
- Language: English
- Type: Book Chapter
- Identifier: http://hdl.handle.net/10210/289211 , uj:31375 , Citation: Abrahamse, H. & Mfouo Tynga, I.S. 2018. Photodynamic therapy, a potential therapy for improve cancer management. , DOI: http://dx.doi.org/10.5772/intechopen.74697
- Description: Abstract: Cancer is a mass of abnormal and detrimental cells in a given part of the body. The main elucidated cause is the uncontrolled growth and proliferation of those cells after the corruption of the physiological processes responsible for normal development and functioning. The advantage of adjuvant therapy, therapy done after surgery, is to prevent the occurring of symptoms and not necessarily to make sure of the integrity of mechanisms that are crucial in preventing abnormal cell proliferation such cell cycle regulation, cell death, which include autophagy, necrosis, and apoptosis. The understanding of dysregulated cell death mechanisms combined with suitable alternative cancer therapies could lead to novel treatment modalities for cancer. Currently, breast cancer is the leading occurring cancer in sub-Saharan women after that of the cervix. This potentially curable condition kills more than half of the diagnosed group, which consists mainly of females aged between 35 and 49 years and with 77% being in stages III and IV. The social economic status of populations coupled with the limited access to proper control strategies and infrastructures in sub-Saharan regions accentuate the burden of the disease. Photodynamic therapy (PDT) has shown great potential in treating breast cancer and even greater therapeutic outcomes can be obtained when combining PDT with other therapies such as immunotherapy or nanomedicine.
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