- Title
- Synthesis of sulfoxide and sulfone mycothiol bioisosteres and novel carbohydrate-based thiochromans
- Creator
- Moshapo, Paseka Thendo
- Subject
- Biosynthesis, Enzymes - Synthesis, Thiols - Synthesis, Heterocyclic compounds - Synthesis
- Date
- 2013-12-09
- Type
- Thesis
- Identifier
- uj:7861
- Identifier
- http://hdl.handle.net/10210/8754
- Description
- M.Sc. (Chemistry), Inhibition of mycothiol biosynthesis pathway has attracted attention from chemists and biochemists who aim to develop novel anti-TB drugs. A possible route to inhibit the production of mycothiol in cells may be via the inhibition of enzymes involved in the biosynthetic pathways. Molecular analogues that mimic mycothiol and containing tetrahedral-forming functional groups have been reported to show activity against mycothiol biosynthesis by inhibiting the enzymes in the mycothiol biosynthetic pathway...
- Contributor
- Kinfe, Henok H., Dr.
- Rights
- University of Johannesburg
- Full Text
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