- Title
- Chemie in die bereiding, skeiding en gehaltebeheer van draervrye radioisotope en radiofarmaseutiese middels
- Creator
- Van der Walt, Tjaart Nicolaas
- Subject
- Ion exchange chromatography, Radioisotopes, Radiopharmaceuticals
- Date
- 2014-06-02
- Type
- Thesis
- Identifier
- uj:11330
- Identifier
- http://hdl.handle.net/10210/10922
- Description
- M.Sc. (Chemistry), This thesis describes the preparation of lead-203 and thallium-201 via proton induced nuclear reactions on natural lead cyclotron targets. The separation of bismuth-206, lead-203 and thallium-201 from the lead target material was investigated in this study. Excellent separations, by ion exchange chromatography, were developed to prepare carrier-free bismuth-206, lead-203and thallium-201. The separation of lead-203 and thallium-201 from thallium cyclotron target material was also investigated in this study, and excellent separations, using ion exchange chromatography, were achieved. The development of spectrophotometric methods for the determination of copper and europium in radiopharmaceuticals was investigated and sensitive methods were compiled. The determination of BIDA, DISIDA, DTPA and HOP in 99-Tc· labelled compounds was also studied in this thesis, and indirect spectrophotometric methods were developed. The determination of BIDA and DISIDA in labelling kits was studied and a complexometric titration, with copper as titrant and eriochrome cyanine R as indicator, was developed. The preparation of calciumtrisodium diethyltriaminepentaacetic acid, for use in DTPA labelling kits, and the development of quality control tests on the product were included in this study. A complexometric method was compiled to determine the calcium and DTPA contents of the CaNa3DTPA. Successive titrations of DTPA (with thorium) and calcium (with DCTA) are carried out using the same sample solution; methyl thymol blue is used as indicator.
- Contributor
- Coetzee, P.P., Prof.; Fourie, P.J., Dr.
- Rights
- University of Johannesburg
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