Abstract
Curcumin, a low molecular weight, lipophilic, major yellow natural polyphenolic, and
the most well-known plant-derived compound, is extracted from the rhizomes of the turmeric
(Curcuma longa) plant. Curcumin has been demonstrated as an effective therapeutic agent in
traditional medicine for the treatment and prevention of different diseases. It has also shown a
wide range of biological and pharmacological effects in drug delivery, and has actively been used
for the treatment of aging-associated diseases, including cardiovascular diseases, atherosclerosis,
neurodegenerative diseases, cancer, rheumatoid arthritis, ocular diseases, osteoporosis, diabetes,
hypertension, chronic kidney diseases, chronic inflammation and infection. The functional application
and therapeutic potential of curcumin in the treatment of aging-associated diseases is well
documented in the literature. This review article focuses mainly on the potential role of plant-derived
natural compounds such as curcumin, their mechanism of action and recent advances in the treatment
of aging-associated diseases. Moreover, the review briefly recaps on the recent progress made in the
preparation of nanocurcumins and their therapeutic potential in clinical research for the treatment of
aging-associated diseases.