The complex relationship between depression and progression to incident cognitive impairment across race and ethnicity

Ganesh M Babulal; Yiqi Zhu; Catherine M Roe; Darrell L Hudson; Monique M Williams; Samantha A Murphy; Jason Doherty; Ann M Johnson; Jean-Francois Trani

doi:10.1002/alz.12631

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The complex relationship between depression and progression to incident cognitive impairment across race and ethnicity

Journal article

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Peer reviewed

The complex relationship between depression and progression to incident cognitive impairment across race and ethnicity

Ganesh M Babulal, Yiqi Zhu, Catherine M Roe, Darrell L Hudson, Monique M Williams, Samantha A Murphy, Jason Doherty, Ann M Johnson and Jean-Francois Trani

Alzheimer's & dementia, Vol.18(12), pp.2593-2602

2022

DOI: https://doi.org/10.1002/alz.12631

Handle:

https://hdl.handle.net/10210/502816

PMID: 35213795

Abstract

Aged

American Indian or Alaska Native

Asian

Black or African American

Cognitive Dysfunction - epidemiology

Cross-Sectional Studies

Depression - epidemiology

Ethnicity

Hispanic or Latino

Humans

White People

We examined baseline differences in depression and antidepressant use among cognitively normal older adults in five ethnoracial groups and assessed whether depression predicted a faster progression to incident cognitive impairment across groups. Data from the National Alzheimer's Coordinating Center (n = 8168) were used to examine differences between non-Hispanic Whites (nHW), African Americans (AA), Hispanics, Asians, and American Indian and Alaskan Natives in cross-sectional and longitudinal models. AA had a lower risk of depression compared to nHW at baseline. No statistical interactions were noted between ethnoracial groups and depression. However, depression independently predicted a faster progression to incident cognitive impairment. Hispanics and Asian participants had a higher hazard for progression compared to nHW. Previously established risk factors between depression and dementia were not found among AA and nHW participants. The relationship between depression and ethnoracial groups is complex and suggests differential effects on progression from cognitive normality to impairment.

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Title: The complex relationship between depression and progression to incident cognitive impairment across race and ethnicity
Creators - without role: Ganesh M Babulal - Institute of Public Health, Washington University in St. Louis, St. Louis, Missouri, USA
Yiqi Zhu - Brown School, Washington University in St. Louis, St. Louis, Missouri, USA
Catherine M Roe - Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA
Darrell L Hudson - Institute of Public Health, Washington University in St. Louis, St. Louis, Missouri, USA
Monique M Williams - New Horizons Living, St. Louis, Missouri, USA
Samantha A Murphy - Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA
Jason Doherty - Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA
Ann M Johnson - Center for Clinical Studies, Washington University in St. Louis, Saint Louis, Missouri, USA
Jean-Francois Trani - Centre for Social Development in Africa, University of Johannesburg, Johannesburg, South Africa
Publication Details: Alzheimer's & dementia, Vol.18(12), pp.2593-2602
Grant note: P50 AG047366 / NIA NIH HHS P50 AG005131 / NIA NIH HHS P30 AG019610 / NIA NIH HHS P50 AG005136 / NIA NIH HHS P50 AG008702 / NIA NIH HHS P50 AG023501 / NIA NIH HHS P50 AG047270 / NIA NIH HHS P50 AG005681 / NIA NIH HHS P30 AG008017 / NIA NIH HHS P30 AG072976 / NIA NIH HHS R01AG067428 / NIA NIH HHS R01 AG074302 / NIA NIH HHS R01 AG056466 / NIA NIH HHS P30 AG072975 / NIA NIH HHS P50 AG005146 / NIA NIH HHS P50 AG016573 / NIA NIH HHS P30 AG066515 / NIA NIH HHS P30 AG066530 / NIA NIH HHS P50 AG005134 / NIA NIH HHS P30 AG066444 / NIA NIH HHS P50 AG033514 / NIA NIH HHS P30 AG072978 / NIA NIH HHS P30 AG010161 / NIA NIH HHS P30 AG013854 / NIA NIH HHS L30 AG074138 / NIA NIH HHS R01 AG067428 / NIA NIH HHS P30 AG066462 / NIA NIH HHS R01 AG068183 / NIA NIH HHS R01AG074302 / NIA NIH HHS R01AG068183 / NIA NIH HHS P30 AG028383 / NIA NIH HHS P30 AG012300 / NIA NIH HHS P30 AG010129 / NIA NIH HHS P30 AG062715 / NIA NIH HHS P30 AG010133 / NIA NIH HHS P50 AG005133 / NIA NIH HHS P50 AG005142 / NIA NIH HHS P50 AG025688 / NIA NIH HHS P30 AG072980 / NIA NIH HHS P30 AG010124 / NIA NIH HHS A2021142S / NIA NIH HHS P30 AG013846 / NIA NIH HHS P50 AG005138 / NIA NIH HHS P30 AG008051 / NIA NIH HHS P30 AG049638 / NIA NIH HHS P50 AG016574 / NIA NIH HHS P30 AG066514 / NIA NIH HHS P30 AG035982 / NIA NIH HHS P50 AG047266 / NIA NIH HHS R01AG056466 / NIA NIH HHS P30 AG053760 / NIA NIH HHS
Identifiers: 9920409607691
Publication Details: 1552-5260
Academic Unit: Department of Psychology; Faculty of Humanities; University of Johannesburg
Language: English
Resource Type: Journal article