Abstract
Three tetradentate Schiff base ligands and gold (III) complexes have been synthesized by a 2:1 molar condensation of salicylaldehyde with ethylenediamine and o- phenylenediamine. The ligands are N,N’-bis (salicylaldehyde) ethylenediamine (1), N,N’-bis (salicylaldehyde) o-phenylenediamine (2) and N,N’-bis (salicylaldehyde)-dimethylbenzene-1,2-diamine. The prepared ligands and their complexes have been characterized by elemental analyses, melting points, infrared spectroscopy and 1H NMR. The spectral data of the ligands and their complexes are discussed in relation to structural changes due to complications. In vitro cytotoxic study results show that the gold complexes exhibit moderate activity and block the proliferation of WHCO1 cells with an IC50 range of 19.02 - 45.27μM, and IC50 range of 10.03 – 68.54μM for the WHCO6 lines.