Abstract
Diabetic foot ulceration is a serious complication of Diabetes Mellitus and a most
important risk factor for lower limb amputations. Diabetes is characterized by chronic
hyperglycemia related to the resistance of target cells to the action of insulin; which leads
to degenerative disorders caused by macroangiopathy, microangiopathy and neuropathy.
These factors favor the occurrence of lower limb ulcers and so delay their healing. The
slow healing rate of chronic diabetic foot ulceration has a negative impact on the patients’
quality of life. Thus there is a need for the development of new treatment modalities to
improve healing rate and outcome of diabetic ulcerations...