Abstract
Lung cancer remains the leading threat of death globally, killing more people
than colon, breast, and prostate cancers combined. Novel lung cancer
treatments are being researched because of the ineffectiveness of
conventional cancer treatments and the failure of remission. Photodynamic
therapy (PDT), a cancer treatment method that is still underutilized, is a
sophisticated cancer treatment that shows selective destruction of
malignant cells via reactive oxygen species production. PDT has been
extensively studied in vitro and clinically. Various PDT strategies have been
shown to be effective in the treatment of lung cancer. PDT has been shown in
clinical trials to considerably enhance the quality of life and survival in individuals
with incurable malignancies. Furthermore, PDT, in conjunction with the use of
nanoparticles, is currently being researched for use as an effective cancer
treatment, with promising results. PDT and the new avenue of nanoPDT,
which are novel treatment options for lung cancer with such promising
results, should be tested in clinical trials to determine their efficacy and side
effects. In this review, we examine the status and future potentials of nanoPDT
in lung cancer treatment.