Abstract
This study explores the opportunities for South Africa to promote economic activities in the context of the fourth industrial revolution. Hence, the study examined science, technology & innovation (STI) as the main driver of the fourth industrial revolution. Meta-analysis was conducted to elicit information from key government policy documents on STI since 1994 to check the political will of South Africa's government. Grey literature from government departments were also reviewed to examine the strength of South Africa’s Research and Innovation System. Based on the assessment of data and information gathered, the study concludes that though strong institutions characterize South Africa's research and innovation system, but the relatively low intensity of linkages and interaction among the key actors of the innovation system continues to pose a threat to South Africa taking a leadership position to significantly contribute to the fourth industrial revolution. However, strong coordination among South Africa’s financial, human, natural, physical, and institutional resources will situate the country in a position to develop the necessary capabilities for the fourth industrial revolution