Abstract
Antimicrobial resistance is a global threat to public health, which has been worsened globally by the overuse of antibiotics. The overprescribing of antibiotics has become a problem in primary care due to emerging infectious diseases. Antimicrobial resistance has caused complications, severe infection, longer hospital stays, and a high death rate. Organisms such as Mycobacterium tuberculosis, Staphylococcus aureus, and Escherichia coli are some of the pathogenic bacteria that have developed resistance against antimicrobial agents including methicillin, vancomycin, cephalosporins, isoniazid, and rifampicin. This study was aimed at extracting crude extracts from plant materials, to test for activity against the Mycobacterium smegmatis ATCC 607, Staphylococcus aureus ATCC 6571, and Escherichia coli ATCC 10536 strains, screening for phytochemicals for those showing activity against the targeted organisms and metabolites profiling using liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS/MS)...
M.Sc. (Biotechnology)