Abstract
M.Sc. (Chemistry)
This thesis describes the preparation of lead-203 and thallium-201 via
proton induced nuclear reactions on natural lead cyclotron targets.
The separation of bismuth-206, lead-203 and thallium-201 from the lead
target material was investigated in this study. Excellent
separations, by ion exchange chromatography, were developed to prepare
carrier-free bismuth-206, lead-203and thallium-201.
The separation of lead-203 and thallium-201 from thallium cyclotron
target material was also investigated in this study, and excellent
separations, using ion exchange chromatography, were achieved.
The development of spectrophotometric methods for the determination of
copper and europium in radiopharmaceuticals was investigated and
sensitive methods were compiled. The determination of BIDA, DISIDA,
DTPA and HOP in 99-Tc· labelled compounds was also studied in this
thesis, and indirect spectrophotometric methods were developed.
The determination of BIDA and DISIDA in labelling kits was studied and
a complexometric titration, with copper as titrant and eriochrome
cyanine R as indicator, was developed. The preparation of calciumtrisodium
diethyltriaminepentaacetic acid, for use in DTPA labelling
kits, and the development of quality control tests on the product were
included in this study. A complexometric method was compiled to
determine the calcium and DTPA contents of the CaNa3DTPA. Successive
titrations of DTPA (with thorium) and calcium (with DCTA) are
carried out using the same sample solution; methyl thymol blue is used
as indicator.