Abstract
Transition metal catalysts which involve the use of electron rich, bulky trialkylphosphine ligands such as P(t-Bu)3 and P(Cy)3 have been successful in various Pd cross-coupling reactions. However, trialkylphosphine ligands are susceptible to rapid oxidation, presenting serious challenges during handling. Researchers in academia and industry have directed efforts in developing novel phosphines, and this resulted in remarkable breakthroughs in discovering several bulky trialkylphosphines and biaryldialkylphosphines. Of these, biaryldialkylphosphine ligand systems developed by Buchwald and Hartwig provide high, stable catalytic ability and efficiency. These ligands systems also feature electron donating and steric bulk properties. In this work we, report the use of limonene (Lim) derived, electron rich, bicyclic phosphine ligands in Pd-catalysed Heck cross-coupling and its application in synthesis of industrially valuable products (Figure 1)...
M.Sc. (Chemistry)