Abstract
This study investigates the potency of some medicinal plants that are commonly used in traditional medicine as antibacterial and antiplasmodial agents. The stem barks of these plant samples were extracted using different solvents in an ascending polarity such as hexane, ethyl acetate, chloroform, methanol and butanol; water (50/50 v/v). Phytochemical analysis was carried out on each of the extracted sample and GC-MS review was performed on each of the crude extracts. Micro serial dilution was used on each crude extract to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration. Moreover, in vivo antiplasmodial activity of each of the crude extracts was also conducted using mice as the experimental animal. Anogeissus leiocarpus has the highest antiplasmodial activity with 82.60% inhibition and unique broad spectral antibacterial activity was obtained by Boswellia dalzielii .Quantitative phytochemical analysis of the crude extracts revealed the presence of significant secondary metabolites which include terpenoids, steroids, alkaloids, phenols, flavonoids, saponins and glycosides. These plants, if properly harness can provide some novel antibiotic and antimalarial drugs.
Ph.D. (Chemistry)