Abstract
Various compounds of Schiff bases were synthesized and characterized by analytical techniques and they were grouped into three sets. The first set of the compounds containing 4-aminoantipyrine moiety with various salicylaldehyde derivatives were synthesized via a condensation reaction of 4- aminoantipyrine with different benzaldehydes through a conventional method of refluxing the mixture for 4 h. Twelve new compounds were synthesized M1-M12. Their antibacterial and antifungal activities were investigated. The antimicrobial activities of synthesized compounds against microbes were concentration dependent relative to the compounds structure and they were found to inhibit the activities of the most studied microbes. The antifungal test revealed that tested fungi were not sensitive to the prepared compounds M1-M12 at the concentration of 500 μg/mL. The second set of the compounds L1-L10 were synthesized via arylation of ferrocene by diazonium salt under phase transfer condition followed by reduction of nitro derivations with Sn/HCl in order to obtain 3-ferrocenylaniline. The formation of 3-ferrocenylphenylimine was achieved through the reaction of aromatic aldehydes with 3-ferrocenylaniline. Compounds L1-L10 antibacterial activities and electrochemical application were investigated. The antibacterial activity of compounds L1-L10 showed excellent activities as compared to the activities of the streptomycin and nalidixic acid used as standards against most of the tested microorganisms. The electrochemical analysis of the compounds showed reversible and quasi-reversible voltammograms of L1, L4, L5, L9 and L10 which indicated good highest occupied molecular orbital HOMO and lowest unoccupied molecular orbital LUMO energy levels...
Ph.D. (Chemistry)